Gusheng Wu Selected Research

LIGA 20

9/2011	Mice lacking major brain gangliosides develop parkinsonism.
11/2007	GM1 in the nuclear envelope regulates nuclear calcium through association with a nuclear sodium-calcium exchanger.
4/2006	Gangliosides of the nuclear membrane: a crucial locus of cytoprotective modulation.
3/2006	GM1 ganglioside: another nuclear lipid that modulates nuclear calcium. GM1 potentiates the nuclear sodium-calcium exchanger.
11/2005	Enhanced susceptibility to kainate-induced seizures, neuronal apoptosis, and death in mice lacking gangliotetraose gangliosides: protection with LIGA 20, a membrane-permeant analog of GM1.

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Gusheng Wu Research Topics

Disease

6	Parkinson Disease (Parkinson's Disease) 01/2022 - 10/2012
4	Neuroblastoma 02/2016 - 06/2002
4	Seizures (Absence Seizure) 11/2007 - 11/2005
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018 - 07/2015
1	Brain Injuries (Brain Injury) 08/2015
1	Neoplasms (Cancer) 04/2012
1	Carcinoma (Carcinomatosis) 04/2012
1	Parkinsonian Disorders (Parkinsonism) 09/2011
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 04/2009
1	Tremor (Tremors) 01/2009
1	Canavan Disease (Leukodystrophy, Spongiform) 01/2009
1	Status Epilepticus (Complex Partial Status Epilepticus) 11/2005

Drug/Important Bio-Agent (IBA)

9	G(M1) GangliosideIBA 01/2022 - 09/2002
7	GangliosidesIBA 01/2022 - 11/2005
5	LIGA 20IBA 09/2011 - 11/2005
3	Kainic Acid (Kainate)IBA 11/2007 - 11/2005
2	Nerve Growth Factor Receptors (Neurotrophin Receptors)IBA 01/2018 - 07/2015
2	Galectin 1 (LGALS1)IBA 04/2012 - 04/2009
1	OligosaccharidesIBA 12/2019
1	SynucleinsIBA 01/2018
1	G(M2) Ganglioside (Ganglioside GM2)IBA 08/2015
1	Ethanol (Ethyl Alcohol)IBA 08/2015
1	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 01/2015
1	Galectins (Galectin)IBA 04/2012
1	Glycoproteins (Glycoprotein)IBA 04/2012
1	IntegrinsIBA 04/2012
1	1-nitrohydroxyphenyl-N-benzoylalanine (GAL 1)IBA 04/2009
1	aspartoacylaseIBA 01/2009
1	Sulfoglycosphingolipids (Sulfatides)IBA 01/2009
1	LipidsIBA 01/2009
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2009
1	EnzymesIBA 01/2009
1	CerebrosidesIBA 01/2009
1	gangliotetraoseIBA 11/2005
1	LigandsIBA 09/2002
1	Cholera ToxinIBA 09/2002
1	Sodium-Calcium ExchangerIBA 06/2002

Therapy/Procedure

1	Therapeutics 07/2015
1	Intraperitoneal Injections 11/2005